| Acronym | Meaning |
| DLN | Don’t Look Now |
| DLS | Dirty Little Secret |
| DLTBBB | Don’t Let The Bed Bugs Bite |
| DLTBGYD | Don’t Let The Bastards Grind You Down |
| DLTM | Don’t Lie To Me |
| DLV | Demonstration of Lower Value |
| DM | Don’t Mind Doesn’t Matter Direct Message |
| DMAF | Don’t Make A Fuss |
| DMAL | Drop Me A Line |
| DMB | Dave Matthews Band |
| DMC | Deep Meaningful Conversation |
| DMCA | Digital Millennium Copyright Act |
| DMI | Don’t Mention It |
| DMIID | Don’t Mind If I Do |
| DMM | Don’t Mind Me |
| DMML | Don’t Make Me Laugh |
| DMS | Dirty Money Syndicate |
| DMT | Di-Methyl Tryptamine (drug) |
| DMTA | Dirty Minds Think Alike |
| DMV | Department of Motor Vehicles |
| DMW | Dead Man Walking |
| DMX | Dark Man X (rapper) |
| DMY | Don’t Mess Yourself |
| DMZ | De-militarized zone |
| DN | Doing Nothing |
| DNA | Deoxyribonucleic Acid Did Not Attend Does Not Apply |
| DNC | Democratic National Committee |
| DND | Do Not Disturb |
| DNDC | Don’t Know, Don’t Care |
| DNE | Do Not Erase Does Not Exist |
| DNF | Did Not Finish |
| DNFTT | Do Not Feed The Troll |
| DNK | Do Not Know |
| DNM | Does Not Matter Deep and Meaningful |
| DNP | Do Not Post |
| DNR | Do Not Resuscitate |
| DNS | Domain Name Service Did Not Start |
| DNTK | Don’t Need To Know |
| DNW | Do Not Want |
| DOA | Dead On Arrival Deteriorate On Approach |
| DOB | Date Of Birth |
| DOC | Doctor Drug of Choice |
| DOD | Day of Defeat |
| DOE | Depends On Experience |
| DOF | Depth of Field |
| DOFL | Dying On Floor Laughing |
| DRT | Dead Right There |
| DS | Darling Son |
| DSD | Do Some Damage |
| DSL | Digital Subscriber Line |
| DSLR | Digital Single Lens Reflex (camera) |
| DSP | Digital Signal Processing |
| DSS | Department of Social Services |
| DST | Daylight Saving Time |
| DT | Down Town |
| DTA | Don’t Trust Anyone |
| DTAM | Death To All Men |
| DTB | Don’t Text Back |
| DTC | Down To Cuddle |
| DTD | Drunk Till Dawn Drunk Till Death |
| DTE | Down To Earth |
| DTH | Down To Hang |
| DTL | Does The Look |
| DTM | Doing Too Much Dead To Me |
| DTMS | Does That Make Sense? |
| DTMWTD | Don’t Tell Me What To Do |
| DTP | Disturbing The Peace |
| DTR | Define The Relationship |
| DTRT | Do The Right Thing |
| DTS | Down The Shore Down To Snuggle |
| DTT | Don’t Touch That |
| DTTC | Don’t Text The Cell |
| DTTM | Don’t Talk To Me |
| DTYT | Don’t Take Your Time |