| Acronym | Meaning |
| EBM | Electronic Body Music |
| EBT | Electronic Benefits Transfer |
| ELOL | Evil Laugh Out Loud |
| EOB | End Of Business |
| EOC | End Of Conversion |
| EOD | End Of Discussion |
| EOE | Equal Opportunity Employer |
| EOF | End Of File |
| EOG | End Of Grade |
| EOL | End Of Lecture |
| EOM | End Of Message |
| EOR | End Of Rant |
| EOS | End Of Show |
| EOT | End Of Thread (i.e. end of discussion) |
| EOTD | End Of The Day |
| EOTW | End Of The World |
| EOTWAWKI | End Of The World As We Know It |
| EOW | End Of Watch |
| EPOS | Electronic Point Of Sale |
| EPROM | Electronically Programmable ROM |
| ERP | Erotic Role-Play |
| ESA | European Space Agency |
| ESB | Empire Stikes Back (Star Wars) |
| ESD | Electro-Static Discharge |
| ESL | English as Second Language |
| ESOL | English for Speakers of Other Languages |
| ESP | Extra Sensory Perception |
| ESPN | Entertainment and Sports Programming Network |
| ESRB | Entertainment Software Rating Board |
| EST | Eastern Standard Time Established |
| ESTD | Easier Said Than Done |
| ET | Extra Terrestrial |
| ETA | Estimated Time of Arrival Edited to Add |
| ETC | Et Cetera (and so on) |
| ETD | Estimated Time of Departure |
| ETF | Escape The Fate (band) |
| ETID | EveryTime I Die (band) |
| ETW | Enjoy The Weekend |
| EU | European Union |
| EUA | End User Agreement |
| EUC | Excellent Used Condition |
| EULA | End User License Agreement |
| EV | Expected Value |