| Acronym | Meaning |
| SA | Sibling Alert |
| SAB | Smoking A Blunt |
| SAE | Stamped/Self Addressed Envelope |
| SAF | Single Asian Female |
| SAFM | Stay Away From Me |
| SAHD | Stay At Home Dad |
| SAHM | Stay At Home Mom |
| SAHW | Stay At Home Wife |
| SALTS | Smiled A Little Then Stopped |
| SAM | Stop Annoying Me |
| SAP | Sad And Pathetic Fool |
| SASE | Self-Addressed, Stamped Envelope |
| SAT | Scholastic Assessment Test |
| SATA | Serial Advanced Technology Attachment |
| SATC | Sex And The City (TV show) |
| SATS | Standard Attainment Tests |
| SBD | Silent But Deadly |
| SBF | Single Black Female |
| SBI | Surrounded By Incompetence |
| SBJ | Sweet Baby Jesus |
| SBM | Single Black Male |
| SBS | Step By Step |
| SBSP | SpongeBob SquarePants |
| SBT | Sorry ‘Bout That |
| SCNR | Sorry, Could Not Resist |
| SCOTUS | Supreme Court Of The United States |
| SCSI | Small Computer System Interface |
| SCUBA | Self-Contained Underwater Breathing Apparatus |
| SD | Sweet Dreams Secure Digital (memory card) So Drunk |
| SDA | Seventh-Day Adventist |
| SDK | Software Development Kit |
| SDMF | Strength, Determination, Merciless, Forever Society Dwelling Mother F***er |
| SDRAM | Synchronous Dynamic Random Access Memory |
| SEO | Search Engine Optimization |
| SEP | Somebody Else’s Problem |
| SERP | Search Engine Results Page |
| SF | Science Fiction San Francisco |
| SFAM | Sister From Another Mister |
| SFLR | Sorry For Late Reply |
| SFO | San Francisco International Airport |
| SFP | Sorry for Partying |
| SFR | Smiling For Real |
| SFSG | So Far So Good |
| SFTBC | Sorry For The Broadcast |
| SFW | Safe For Work |
| SGTM | Sounds Good To Me |
| SH | Same Here |
| SHU | Secure Housing Unit |
| SIWOTI | Someone Is Wrong On The Internet |
| SLOL | Seriously Laughing Out Loud |
| SLR | Single Lens Reflex (camera) |
| SMAO | Study My Ass Off |
| SMDH | Shaking My Damn Head |
| SMDHE | Some Mothers Do Have Em |
| SME | Small/Medium Enterprises |
| SMGDH | Shaking My God Damn Head |
| SMH | Shaking My Head |
| SMHID | Shaking My Head In Despair |
| SMHL | Shaking My Head Laughing |
| SMIB | Southern Maryland Inbred |
| SMIDSY | Sorry Mate, I Didn’t See You |
| SML | Screw My Life Story of My Life |
| SMN | Shoot Me Now |
| SMOG | Sweet Mother Of God |
| SMOP | Simple Matter Of Programming |
| SMS | Short Message Service |
| SMT | Sucking My Teeth |
| SMTP | Simple Mail Transfer Protocol |
| SNAFU | Situation Normal, All Fouled Up |
| SNAG | Sensitive New Age Guy Sausage |
| SNC | Social Network Check |
| SND | Search And Destroy |
| SNES | Super Nintendo Entertainment System |
| SNF | So Not Funny |
| SNM | Say No More |
| SNR | Signal To Noise Ratio |
| SNYK | So Now You Know |
| SO | Significant Other Shout Out |
| SOA | State Of Alert (band) |
| SOAD | System Of A Down (Band) |
| SOAG | Son Of A Gun |
| SOG | Sea Of Green (cannabis growing) |
| SOH | Sense Of Humor |
| SOHF | Sense Of Humor Failure |
| SOI | Statement of Intent |
| SOIDH | Screenshot Or It Didn’t Happen |
| SOMD | Sh*t On My Dick |
| SOML | Story Of My Life |
| SOMSW | Someone Over My Shoulder Watching |
| SOOC | Straight Out Of Camera (not Photoshopped) |
| SOOD | Cool |
| SOOTB | Straight Out Of The Box |
| SOP | Standard Operating Procedure |
| SOPA | Stop Online Piracy Act |
| SORN | Statutory Off Road Notification |
| SOS | Save Our Souls (Help!) |
| SOTA | State Of The Art |
| SRH | Supporting Radical Habits (Clothing) |
| SRM | Stark Raving Mad |
| SRO | Standing Room Only |
| SRT | Street and Racing Technology |
| SS | Screen Shot |
| SSA | Subject Says All |
| SSBB | Super Smash Brothers Brawl (game) |
| SSBHM | Super Sized |
| SSC | Safe, Sane, Consensual |
| SSD | Solid State Drive |
| SSDD | Same Stuff Different Day |
| SSH | Secure Shell (Unix program) |
| SSID | Service Set Identifier |
| SSL | Secure Socket Layer See Subject Line |
| SSTS | Snickering Softly To Self |
| SSWA | So Say We All |
| STW | Search The Web |
| STY | Same To You |
| STYL | Speak To You Later |
| SU | Shut Up |
| SUAD | Shut Up And Drive |
| SUL | See You Later |
| SULA | Sweaty Upper Lip Alert |